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2.5D Dual-Encoder U-Net for Lesion Segmentation in Chest CT Scans
(Indian Statistical Institute, Kolkata, 2025-06) Mukkara, Jagannath
Accurate segmentation of lesions in chest CT scans plays a vital role in diagnosing and monitoring pulmonary diseases such as COVID-19. In this, we introduce a novel 2.5D[1] dual-encoder U-Net model[2] that utilizes both the central slice and its neighboring slices to improve segmentation accuracy while keeping computational demands manageable. Our model incorporates residual connections[3] and feature fusion[4] to effectively merge multi-slice contextual information, overcoming the limitations found in traditional 2D and 3D methods. To ensure a reliable evaluation and avoid data leakage, we used patient-level data splitting. We validate our approach on a carefully curated chest CT dataset, showing enhanced segmentation performance and better generalization compared to standard U-Net models. Through extensive experiments, including ablation studies and visualizations, we demonstrate the advantages of combining 2.5D learning with a dual-encoder architecture for medical image segmentation tasks.